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Mikael Kubista

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Mikael Kubista
Born (1961-08-13) 13 August 1961 (age 64)
Podboƙany, Czechoslovakia
CitizenshipSwedish
Alma mater
Known for
  • quantitative real-time PCR (qPCR)
  • TATAA Bio-center
Scientific career
FieldsBiochemistry
Institutions

Mikael Kubista (born 13 August 1961) is a Czech-born Swedish chemist and entrepreneur who works in the field of molecular diagnostics. Since 2007 he is serving as Head of the Laboratory of Gene Expression at the Biotechnology Institute, Czech Academy of Sciences.[1]

Early life

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Kubista was born in the former Czechoslovakia in 1961.[2]

In 1984 and 1986, Kubista won the Swedish junior championships in bridge together with Nils Åhlen and Stefan Rebner, and with Stefan Andreasson and Niklas Karlsson, respectively.[3]

Education

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He completed his undergraduate studies at University of Gothenburg, earning a B.Sc. degree in chemistry in 1984.[4] He then pursued a Licentiate in Physical Chemistry at the Institute of Chemistry and Chemical Engineering, Chalmers University of Technology in Göteborg, which he completed in 1986. Kubista obtained his Ph.D. in chemistry from Chalmers University of Technology.[5] Following his doctoral studies, he conducted postdoctoral research at La Trobe University in Melbourne, Australia, and Yale University in New Haven, US.[2][6] Additionally, he has held visiting professor positions at various universities, including the University of Maryland in College Park, US, in June 2000, and the University of A Coruña in Spain, during September–November 2003 and July 2006 to June 2007.[2]

Career

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Academic career

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Kubista began his academic career in 1991 as an assistant professor in the Department of Physical Chemistry at Chalmers University of Technology.[2] From 1993 to 1997, he was an associate professor in the Department of Biochemistry at the same institution. Following this, he held the position of professor in the Department of Biochemistry at Chalmers University of Technology from 1997 to 2006.[2]

Entrepreneurial activities

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In 1998 Kubista founded LightUp Technologies AB after his research finding of LightUp probes,[7] a company that develops real-time PCR tests for human infectious diseases.[8] In 2001, Kubista cofounded TATAA Biocenter with Neven Zoric and professor Anders StÄhlberg, with professors Michael Pfaffl, Stephen Bustin and Vladimir Benes as scientific advisors.[9][failed verification] TATAA Biocenter accepted financing from Care Equity in 2021.[10]

In 2020, Kubista co-founded SimSen Diagnostics a company focused on developing technology for liquid biopsy analyses.[11]

TATAA Biocenter

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In 2021, Care Equity, controlled by investor Peter Batesko, invested in TATAA Biocenter.[12][9] To facilitate the investment, a new holding company, Bioholdings LP, was established to acquire TATAA. During restructuring connected to TATAA’s COVID-19 testing business, Kubista and his co-founders, advised by a law firm, carried out an upstream merger between two holding entities. This violated a clause in the agreement that prohibited share transfers without written consent. Peter Batesko, General Partner of Care Equity, refused to register the founders' ownership. In June 2023 Batesko dismissed Kubista as CEO and forfeited the founders' shares without compensation.[13] Peter Batesko and companies he controls then sued Kubista, the TATAA founders and their lawyer in what Kubista's lawyer claims to be a SLAPP lawsuit.[14] As of October 2025, legal proceedings related to the merger dispute remain ongoing in the Swedish courts.[15] Kubista also sued the law firm for negligent advice.[16]

Precision BioAnalytics

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In 2025 Kubista together with Jens Björkman, Robert Sjöback and Fredrik Adlercreutz founded Precision BioAnalytics,[17][18][19] around a new preanalytical procedure that increases sensitivity and improves precision of the preanalytical process in molecular analysis,[20] with seed financing from the Swedish infra-structure CCRM-Nordic.[21]

Selected findings and publications

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Kubista has close to 300 publications.[22]

  • Studied and identified chromophores and a variety of dyes commonly used as biomolecule labels like: tryptophan, DAPI, fluorescein,[23] thiazole orange, and BEBO.[7]
  • Uncovered mechanism of oncogene activation involving the formation of internal G-quadruplexes.[24]
  • Designed a probe that exhibit luminescence upon binding to specific nucleic acids.[25]
  • Techniques for gene expression at the level of individual cells and subcellular compartments.[26]
  • Discovered the Regeneration Initiating Cells (RICs) [27]

References

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  1. ^ "Laboratory of Gene Expression - Institute of Biotechnology of the Czech Academy of Sciences". www.ibt.cas.cz. Retrieved 2025-11-06.
  2. ^ a b c d e "Academy of Europe: CV". www.ae-info.org. Retrieved 2025-11-06.
  3. ^ "Junior-SM Lag | Svenska Bridgeförbundet". svenskbridge.se. Retrieved 2025-11-06.
  4. ^ "GOTEBORGS UNIVERSITET". labgenexp9. Retrieved 8 March 2024.
  5. ^ "CHALMERS TEKNISKA HOGSCOLA". labgenexp. Retrieved 8 March 2024.
  6. ^ "ORCID". orcid.org. Retrieved 2025-12-01.
  7. ^ a b "Biomolecular Detection and Quantification" (PDF). gene-quantification. Retrieved 2 January 2024.
  8. ^ "Mikael Kubista". BioTech Pharma Summit. Retrieved 2023-12-28.
  9. ^ a b "TATAA Biocenter to offer GLP services to developers of cell and gene therapies across the world". naringsliv. Retrieved 28 December 2023.
  10. ^ "Tataa Biocenter – Care Equity". Retrieved 2025-09-24.
  11. ^ "About us". simsendiagnostics.com. Retrieved 2025-12-01.
  12. ^ Madsen, Christian (2021-09-24). "One of the world's best equipped laboratories for molecular analyses is expanding | AffÀrstidningen NÀringsliv" (in Swedish). Retrieved 2025-10-17.
  13. ^ Göransson, Av Anders (2024-01-31). "Failed to read the fine print – lost his life's work". Life Science Sweden. Retrieved 2025-03-07.
  14. ^ Johansson, Joakim K. E. (2025-02-19). "Riskkapitalisten tog hans företag: "Isolerad, hotad och stÀmd"". Realtid (in Swedish). Retrieved 2025-10-27.
  15. ^ "Mikael Kubista - the pioneering entrepreneur who lost ownership of the company he built". Apple Podcasts. Retrieved 2025-08-20.
  16. ^ Göransson, Anders (2024-12-19). "Partial court victory for entrepreneur who lost his company". Life Science Sweden. Retrieved 2025-11-27.
  17. ^ Agovic, Amina (2025-08-21). "CCRM Nordic and Precision BioAnalytics forge venture partnership to accelerate ATMP development". CCRM nordic (in Swedish). Retrieved 2025-09-24.
  18. ^ "CCRM Nordic invests in Precision BioAnalytics". ATMP Sweden. Retrieved 2025-09-24.
  19. ^ Lagercrantz, Av Samuel (2025-04-28). "Mikael Kubista back with new venture after turbulent exit". Life Science Sweden. Retrieved 2025-08-21.
  20. ^ viktorwallen (2025-06-11). "Innovativ metod som förÀndrar den molekylÀra analysen". Framtidens forskning (in Swedish). Retrieved 2025-11-06.
  21. ^ "CCRM Nordic and Precision BioAnalytics forge venture partnership to accelerate ATMP development". GU Ventures. 2025-08-21. Retrieved 2025-08-21.
  22. ^ "Web Of Science".
  23. ^ Sjöback, Robert; Nygren, Jan; Kubista, Mikael (1995). "Absorption and fluorescence properties of fluorescein". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 51 (6): L7 – L21. Bibcode:1995AcSpA..51L...7S. doi:10.1016/0584-8539(95)01421-P. Retrieved 2 January 2024.
  24. ^ "DNA tetraplex formation in the control region of c-my". academic. Retrieved 2 January 2024.
  25. ^ Svanvik, Nicke; Westman, Gunnar; Wang, Dongyuan; Kubista, Mikael (2000). "Light-Up Probes: Thiazole Orange-Conjugated Peptide Nucleic Acid for Detection of Target Nucleic Acid in Homogeneous Solution". Analytical Biochemistry. 281 (1): 26–35. doi:10.1006/abio.2000.4534. PMID 10847607.
  26. ^ Bengtsson, M.; StĂ„hlberg, A.; Rorsman, P.; Kubista, M. (2005). "Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels". Genome Research. 15 (10): 1388–1392. doi:10.1101/gr.3820805. PMC 1240081. PMID 16204192. Retrieved 2 January 2024.
  27. ^ Sindelka, Radek; Naraine, Ravindra; Abaffy, Pavel; Zucha, Daniel; Kraus, Daniel; Netusil, Jiri; Smetana, Karel; Lacina, Lukas; Endaya, Berwini Beduya; Neuzil, Jiri; Psenicka, Martin; Kubista, Mikael (2024-10-01). "Characterization of regeneration initiating cells during Xenopus laevis tail regeneration". Genome Biology. 25 (1): 251. doi:10.1186/s13059-024-03396-3. ISSN 1474-760X. PMC 11443866. PMID 39350302.
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